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Why are liver and lungs the most common organs for metastasis?

Both organs produce a range of growth factors favorable for tumour growth

The lungs are the first major capillary bed encountered from the vena cava, and the liver the first capillary bed after the portal system

The lungs are well oxygenated supporting rapid tumour growth and the liver has ample energy stores for supporting tumour growth

Both organs normally express cadherins for epithelial, mesothelial and endothelial cells.

RC 10th Ed. p 275