general_pathology:neoplasia:neoplasia_67
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Breast cancers which preferentially spread to bone are more likely to secrete which product?
”Explanation”
RC 10th Ed. p 309
The mammary carcinoma cells produce Parathyoid hormone-related product which stimulates osteoblasts to make RANKL which in turn activate octeoclasts which destroy bone matrix and release growth factors including TGF-β and IGF.
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