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The driver mutation in neuroblastoma is:

Amplification of NMYC via expression in extra double minutes or insertion into other autosomes

Mutations in enhancer elements flanking MYC

Upregulation of MYC via dysregulated Wnt signalling

Upregulation of MYC via dysregulated RAS/MAPK signalling

”Explanation”

Multiple copies of nMyc might be inserted into the other autosome

<!–Mutation of enhancer elements occur in prostate and ovarian carcinomas. Dysregulated Wnt signalling occurs in some colon carcinomas. RAS/MAPK signalling is common in many cancers–>

(HSR: Homogenous staining region)