general_pathology:neoplasia:neoplasia_26
Choose the correct answer
Approximately 30% of breast carcinomas develop because of a gain in function mutation in which gene?
”Explanation”
RC 10th Ed. p 287-288. A gain in function mutation of PI3K means it will set off a cascade of protein activation including Akt which phosphorylates 150 different proteins and mTOR which upregulates protein synthesis and FOXO (Forkhead Box O) transcription which promotes cell survival, metabolism and stress resisitance.
general_pathology/neoplasia/neoplasia_26.txt · Last modified: by achamings