general_pathology:neoplasia:neoplasia_22
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The most common mutation in human pancreatic adenocarcinomas affects which group of proteins?
”Explanation”
Mutations in RAS genes (HRAS, KRAS, NRAS) are the most common mutation found in 20% of neoplasms in people and 90% of pancreatic adenocarcinomas. Mutations often affect the self GTPase activity of the RAS protein which would convert active RAS to inactive RAS. RC 10th Ed. p 287
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