Vet Pathology Wiki

Choose the correct answer

Which of the following is a driver mutation?

A mutation in a gene that interferes with the host immune response

A mutation in a gene that alters the way the tumour interacts with the stroma

A mutation in a gene that maintains genomic integrity

A mutation in a gene that increases the secretory capability of the tumour

A driver mutation is restricted to a mutation that alters the behaviour of a neoplastic cell in an intrinsic fashion (ie the initiating gain of function mutation of an onocogene or a loss of function in a tumour suppressor gene or a mutation in a gene that enables the tumour to gain further mutations)