Vet Pathology Wiki

Choose the correct answer

Which of the following statements about mutations in oncogenes in neoplasia is true?

Are loss of function mutations and behave in a recessive fashion

Are a gain of function mutation and behave in a dominant fashion

Are a gain in function mutation and behave in a recessive fashion

Are a loss of function mutation and behave in a dominant fashion

Because the mutation in one allele of an oncogene results in that copy gaining function, this mutation behaves in a dominant fashion ie neoplasia may still develop even with a normal allele copy. RC 10th Ed. p 282