Vet Pathology Wiki

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What is granulocytopathy syndrome of dogs or cattle?

An autosomal recessive defect in leukocyte adhesins prevent neutrophils from adherin to the endothelium

An autosomal recessive defect in the hexose monophosphate pathway resulting in a deficiency in NADPH and reduced concentrations of hydrogen peroxide in lysosomes

An autosomal recessive deficiency in bone marrow stem cells resulting in accumulation of pyrimidine and purine metabolites and periodic declines in neutrophils every 10-12 days

An autosomal recessive defect in the Il-6 receptor resulting in a lack of neutrophil response to inflammatory signalling

”Explanation”

PBVD 7th Ed. P189 An autosomal recessive defect in the hexose monophosphate pathway resulting in a deficiency in NADPH and reduced concentrations of hydrogen peroxide in lysosomes