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How does excessive levels of LPS induce septic shock?

By inducing excessive cytokines such as IL-6, IL12 and TNF

By LPS directly activating endothelial cells causing vasodilation and a pro-coagulative state

Activation of phospholipase A and production of prostaglandins and leukotrienes

Mimic tissue factor and inducing activation of platelets

RC 10th Ed. p 347 Remember IL-12 induces a Th1 adaptive immune response.