Vet Pathology Wiki

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P. falciparum is more pathogenic that other Plasmodium species because of:

P. falciparum can bind red blood cells of any age

P. falciparum produces less cytokines during the infection evading the immune response

P.falciparum causes less red cell clotting and therefore the infection is present in the bloodstream longer

PfEMP1 protects red blood cells and therefore the parasite from phagocytes

P. falciparum can:

Bind RBCs of any age
Cause more severe clumping and therefore ischaemia and cerebral malaria
GPI linked glycoproteins from merozoites are potent cytokine inducers which induce fever and ROS production in phagocytes