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Choose the correct answer

Which of the following is true for the process of epitope spreading in autoimmune diseases?

Immune reaction to one epitope reveals other cryptic self epitopes which elicit further immune reaction

A single epitope binds non-specifically to the T-cell receptor allowing it to respond to many different self antigens

The combination of a particular epitope with self antigens enables them to be recognized by the immune system

Mutations in the HLA genes results in misfolding of the heavy chain of the immunoglobulin allowing it to alter its confirmation post translation and therefore respond to several epitopes

”Explanation”