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Choose the correct answer

Which of the following mechanisms will not induce anergy in a self reacting peripheral T cell?

By the APC not producing B7 proteins

By the T cell expressing CTLA-4 and binding to B7 proteins on the APC

By the T cell expressing PD-1 and binding to PD-L1 or PD-L2 on the APC

By the APC expressing B7 proteins and binding to CD28 on the T-cell

If B7 binds to CD28 - the cell is given the signal to produce Il-2 and proliferate which is NOT what the body wants