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By what mechanism are defects in PTPN22 thought to cause disease?

Unable to dampen tyrosine kinase resulting in excessive self-reactive lymphocyte activation

Excessive dampening of tyrosine kinase resulting in regulatory T cell lymphocyte suppression

Unable to dampen tyrosine kinase resulting in excessive regulatory T cell lymphocyte suppression

Excessive dampening of tyrosine kinase resulting in self-reactive lymphocyte activation