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What is the mechanism of Carbon tetrachloride toxicity?

CCl₄ directly oxidizes plasma membrane lipoproteins

CCl₄ is converted to ˙CCl₃ radical by cytochrome P450 in the liver

CCl₄ interferes with mitochondrial cytochrome oxygenases inhibiting oxidative phosphorylation

CCl₄ is concentrated at sites of excretion and absorption and ˙CCl₃ binds to sulfhydryl groups in the plasma membrane

RC 10th Ed. p. 56