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The immunodeficiency syndrome Chronic granulomatous disease (CGD) occurs due to:

Infection with HIV making individual susceptible to Mycobacterial infections

Mutations in genes encoding phagocyte oxidase genes

An autosomal recessive mutation causing an upregulation of IFG-γ and stimulation of macrophages

Mutations in the TGF-β receptor which prevents the conversion of an M1 to an M2 response

RC 10th ed p83, p241