general_pathology:neoplasia:neoplasia

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In Marek's disease which of the following is important in the development of neoplasia?

Viral insertion of DNA near c-Myc

Causes cytolysis of B and T lymphocytes enabling immune evasion

Encodes a homologue of EGF to encourage host cell proliferation

Inserts the oncogene abl into the host genome

PBVD, 7th Ed. p520. Early in the infection of MDV, the virus causes cytolysis of lymphocytes. This helps any transformed cells which have had the Meq oncogene inserted to evade the immune system. Meq mimics c-Jun which is a transcription factor promoting cell growth and proliferation. https://www.mdpi.com/1999-4915/17/2/259