general_pathology:neoplasia:neoplasia

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How does induction of expression of CTLA-4 in T-lymphocytes by tumour cells suppress immune recognition?

CTLA-4 binding to B7 on APCs prevents the second signal necessary to activate the lymphocyte

expression of CTLA-4 on the lymphocyte down regulates the T-cell receptor

CTLA-4 blocks binding of the T-cell Receptor to MHC class-II molecules

CTLA-4 binds to PD-1 blocking the second signal necessary to activate the lmyphocyte

The CTLA-4 receptor is used to induce anergy of self reactive T lymphocytes. RC 10th Ed. p217, p312