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How do tumours develop a capsule?
Neoplastic cells secrete fibroblast growth factors and activate resident fibroblasts
Pressure from the growing neoplasm produces hypoxic damage and activates resident fibroblasts
The immune system signals fibroblasts to wall off a tumour which cannot be destroyed
Regulatory T-cells and M2 macrophages stimulate fibroblasts to produce ECM via Il-10 and TGF-β
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”Explanation”
RC 10th Ed. p273