general_pathology:neoplasia:neoplasia

Choose the correct answer

Which of the following is the best definition of oncogene addiction

The process whereby a neoplasm acquires mutations in multiple oncogenes

Where a tumour relies on a single specific oncogene mutation

The process where DNA integrity genes are lost and the tumour rapidly accumulates multiple mutations in key oncogenes

RC 10th Ed. p 288. Classic example is chronic myeloid leukemia and some acute lymphoblastic leukemias (ABLs). The ABL gene (ch 9) is translocated and fused with BCR gene (ch 22). The BCR-ABL product is a non-receptor tyrosine kinase which can self associate which activates its tyrosine kinase,