general_pathology:neoplasia:neoplasia

Choose the correct answer

Which of the following statements about mutations in tumour suppressor genes in neoplasia is true?

Are loss of function mutations and behave in a recessive fashion

Are a gain of function mutation and behave in a dominant fashion

Are a gain in function mutation and behave in a recessive fashion

Are a loss of function mutation and behave in a dominant fashion

Because the mutation in one allele of a tumour suppressor gene results in that copy losing function, this mutation behaves in a recessive fashion ie The normal allele can still protect against neoplasia. RC 10th Ed. p 282