general_pathology:infectious:infectious_diseases

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How does Ebola virus evade the immune response?

VP24 blocks type I interferons by preventing the IFN-α ot IFN-β receptor from dimerizing

By VP35 inducing apoptosis of T cells via PD-1 signalling

VP24 blocks production of IL-1 and the initiation of the acute inflammatory response

VP35 mimics IκB inhibiting the NF-κB signalling pathway

VP24 - Type I interferons = Interferon α and β which respond early to viral infections.
VP35 - masks viral dsRNA in the cytoplasm