general_pathology:infectious:infectious_diseases

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Which IHC marker can be used to determine if a papilloma is of viral origin?

p16 (CDKN2A)

Rb (Retinoblastoma protein)

E7 (early protein 7)

E6 (early protein 6)

Loss of Rb leads to upregulation of p16 (The presence of Rb provides negative feedback to p16 production).