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Tetanus toxin exerts its effect by:
Degrading SNARE proteins which prevent the release of Acetyl choline from inhibitory interneurons
Degrading SNARE proteins which prevent the release of γ-aminobutyric acid (GABA) from inhibitory interneurons
Degrading SNARE proteins which prevent the release of Acetyl choline into the neuromuscular junction
Degrading SNARE proteins which prevent the release of γ-aminobutyric acid (GABA) into the neuromuscular junction
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”Explanation”
Inhibitory neurotransmitters
From inhibitory neurons
Leaves distal neuron firing unchecked
Spastic paralysis
Toxin travels retrograde up axon