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What is the mechanism inducing thrombosis in heparin induced thrombocytopenia?
Heparin binds to and activates platelets via the Gb1b receptor
Binding of heparin-PF4 induced neoantigen IgG antibodies to platelets and endothelial cells results in their activation
Heparin injures endothelial cells causing them to express pro-thrombotic mediators
High molecular weight heparin used as an anticoagulant suppresses megakaryocytes causing them to produce less platelets.
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