Melanin is biosynthesized from tyrosine in the melanosomes (organelles) of cells called melanocytes, and three enzymes, namely tyrosinase (TYR), tyrosinase‐related protein 1 (TYR1) and tyrosinase‐related protein 2 (TYR2), are involved in the biosynthetic process. Non‐expression of TYR causes albinism, whereas non‐expression of TYR1 leads to a brownish body/hair color. https://sj.jst.go.jp/news/202306/n0614-02k.html

Tyrosinase is a copper dependent enzyme (https://www.ncbi.nlm.nih.gov/books/NBK459156/)