general_pathology:environmental:toxic_and_environmental_diseases

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In the presence of serum hypocalcemia, how does parathyroid hormone increases the production of 1,25-hydroxycholecalciferol?

By causing osteoblasts to express RANKL

By making the intestines absorb more calcium

By increasing the expression of 1α-hydroxylase in the kidney

By decreasing the secretion of calcium in the kidney

PTH stimulates the kidney to express 1α-hydroxylase which converts 25-hydroxycholecalciferol to 1,25-dihydroxycholecalciferol RC 10th Ed. p 439