Choose the correct answer
What is the mechanism of Carbon tetrachloride toxicity?
CCl
4
directly oxidizes plasma membrane lipoproteins
CCl
4
is converted to ˙CCl
3
radical by cytochrome P450 in the liver
CCl
4
interferes with mitochondrial cytochrome oxygenases inhibiting oxidative phosphorylation
CCl
4
is concentrated at sites of excretion and absorption and ˙CCl
3
binds to sulfhydryl groups in the plasma membrane
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”Explanation”
RC 10th Ed. p. 56
RC 10th Ed. p. 56
RC 10th Ed. p. 56