general_pathology:acute:acute_inflammation

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The immunodeficiency syndrome Chronic granulomatous disease (CGD) occurs due to:

Infection with HIV making individual susceptible to Mycobacterial infections

Mutations in genes encoding phagocyte oxidase genes

An autosomal recessive mutation causing an upregulation of IFG-γ and stimulation of macrophages

Mutations in the TGF-β receptor which prevents the conversion of an M1 to an M2 response

RC 10th ed p83, p241. Phagocytes cannot produce reactive oxygen species and therefore the neutrophilic reaction is ineffective and the body switches to a macrophage predominant inflammatory response.