Mutations in RAS genes (HRAS, KRAS, NRAS) are one of the most common mutation found in 20% of all neoplasms in people and 90% of pancreatic adenocarcinomas, 50% of colonic adenocarcinomas. Mutations often affect the self GTPase activity of the RAS protein which would convert active RAS to inactive RAS. RC 10th Ed. p 287