P. falciparum can: * Bind RBCs of any age * Cause **more severe clumping** and therefore ischaemia and cerebral malaria * GPI linked glycoproteins from merozoites are potent cytokine inducers which induce fever and ROS production in phagocytes {{ :general_pathology:infectious:plasmodium_falciparum_lifecycle.png?direct |}} {{ :general_pathology:infectious:p_faciparum_virulence.png?direct |}}