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<quiz-item choice question="Choose the correct answer" text="The driver mutation in neuroblastoma is:" options="Amplification of NMYC via expression in extra double minutes or insertion into other autosomes|Mutations in enhancer elements flanking MYC|Upregulation of MYC via dysregulated Wnt signalling|Upregulation of MYC via dysregulated RAS/MAPK signalling" answer="Amplification of NMYC via expression in extra double minutes or insertion into other autosomes">
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{{ :general_pathology:neoplasia:neuroblastoma_myc.png |}}
Multiple copies of nMyc might be inserted into the other autosome

Other driver mutations to be aware of include:
  * Mutation of enhancer elements occur in prostate and ovarian carcinomas. 
  * Dysregulated Wnt signalling occurs in some colon carcinomas. 
  * Up regulation of RAS/MAPK signalling is common in many cancers

(HSR: Homogenous staining region)
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