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<quiz-item choice question="Choose the correct answer" text="Which of the following statements about mutations in tumour suppressor genes in neoplasia is true?" options="Are loss of function mutations and behave in a recessive fashion|Are a gain of function mutation and behave in a dominant fashion|Are a gain in function mutation and behave in a recessive fashion|Are a loss of function mutation and behave in a dominant fashion" answer="Are loss of function mutations and behave in a recessive fashion">
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Because the mutation in one allele of a tumour suppressor gene results in that copy losing function, this mutation behaves in a recessive fashion ie The normal allele can still protect against neoplasia. RC 10th Ed. p 282
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