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--- general_pathology:neoplasia:neoplasia_31 [2026/02/25 00:11] – created achamings
+++ general_pathology:neoplasia:neoplasia_31 [2026/02/27 05:37] (current) – achamings
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-<quiz-item choice question="Choose the correct answer" text="The driver mutation in neuroblastoma is:" options="Amplification of NMYC via expression in extra double minutes or insertion into other autosomes|Mutations in enhancer elements flanking MYC|Upregulation of MYC via dysregulated Wnt signalling|Upregulation of MYC via dysregulated RAS/MAPK signalling answer="Amplification of NMYC via expression in extra double minutes or insertion into other autosomes">
+<quiz-item choice question="Choose the correct answer" text="The driver mutation in neuroblastoma is:" options="Amplification of NMYC via expression in extra double minutes or insertion into other autosomes|Mutations in enhancer elements flanking MYC|Upregulation of MYC via dysregulated Wnt signalling|Upregulation of MYC via dysregulated RAS/MAPK signalling" answer="Amplification of NMYC via expression in extra double minutes or insertion into other autosomes">
 </quiz>
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 {{ :general_pathology:neoplasia:neuroblastoma_myc.png |}}
-Mutation of enhancer elements occur in prostate and ovarian carcinomas. Dysregulated Wnt signalling occurs in some colon carcinomas. RAS/MAPK signalling is common in many cancers
+Multiple copies of nMyc might be inserted into the other autosome
+Other driver mutations to be aware of include:
+  * Mutation of enhancer elements occur in prostate and ovarian carcinomas.
+  * Dysregulated Wnt signalling occurs in some colon carcinomas.
+  * Up regulation of RAS/MAPK signalling is common in many cancers
+(HSR: Homogenous staining region)
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