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--- general_pathology:neoplasia:neoplasia_14 [2026/02/24 22:38] – achamings
+++ general_pathology:neoplasia:neoplasia_14 [2026/02/24 23:33] (current) – achamings
@@ Line 4: / Line 4: @@
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-Haploinsufficiency - when the loss of one normal allele of a tumour suppressor gene is sufficient to develop neoplasia even with a functionally normal allele.
+Haploinsufficiency - when the loss of one normal allele of a tumour suppressor gene is sufficient to develop neoplasia even with a functionally normal allele. "Haplo" = single.
+Classic example is p53 - loss of function of 1 allele significantly increases the chance of neoplasia.
+{{ :general_pathology:neoplasia:haplo-insufficiency.png |}}
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 </accordion>