Differences

This shows you the differences between two versions of the page.

--- general_pathology:infectious:infectious_diseases_162 [2026/03/10 00:16] – achamings
+++ general_pathology:infectious:infectious_diseases_162 [2026/03/10 00:19] (current) – achamings
@@ Line 4: / Line 4: @@
 <accordion>
 <accordion-item title=”Explanation”>
+The promastigote replicates in the gut of the sandfly and is the infective form of the parasite. Once inside macrophages promastigotes transform to amastigotes and replicate - infecting successive cycles of macrophages. They are highly dependent on iron and have iron transport protein ZRT.
+Their dense lipophosphoglycan glycocalyx stops C3b from forming the MAC. But the parasite keeps C3b to be phagocytosed by macrophages.
 {{ :general_pathology:infectious:leishmania_lifecycle.gif?direct |}}
 </accordion-item>
 </accordion>