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| general_pathology:cells:cell_as_unit_of_health_68 [2026/01/26 08:25] – removed - external edit (Unknown date) 127.0.0.1 | general_pathology:cells:cell_as_unit_of_health_68 [2026/03/14 00:18] (current) – achamings |
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| | <quiz> |
| | <quiz-item choice question="Choose the correct answer" |
| | text="Cystic fibrosis is caused by what mutation?" |
| | options="A single mutation in chaparone proteins within the ER resulting in misfolding of proteins, ER retention and subsequent catabolism|A single mutation in the CFTR protein resulting in the absence of Phe508 and subsequent protein misfolding. The protein is catabolized in the ER and therefore not expressed on the cell surface|A single mutation in the CHP chaparone protein resulting in the absence of Phe508 and subsequent protein misfolding. The protein is catabolized in the ER and results in misfolding of other proteins destined for the plasma membrane|A single mutation in the CFTR protein resulting in the absence of Phe508 and subsequent protein misfolding. The defective protein is expressed on the plasma membrane" |
| | answer="A single mutation in the CFTR protein resulting in the absence of Phe508 and subsequent protein misfolding. The protein is catabolized in the ER and therefore not expressed on the cell surface"> |
| | </quiz> |
| | <accordion> |
| | <accordion-item title=”Explanation”> |
| | {{ :general_pathology:cells:cystic_fibrosis.png?direct |}} |
| | RC 10th Ed. p 13 |
| | </accordion-item> |
| | </accordion> |
