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--- general_pathology:acute:acute_inflammation_70 [2026/03/01 05:08] – created achamings
+++ general_pathology:acute:acute_inflammation_70 [2026/03/01 05:10] (current) – achamings
@@ Line 1: / Line 1: @@
 <quiz>
-<quiz-item choice question="Choose the correct answer" text="PAD4 has which of the following effects in the neutrophil?" options="Methylates DNA|Citrulinates arginine in histones|Phosphorylates Pi3K and Atk|Ruptured the nuclear membrane" answer="Citrulinates arginine in histones">
+<quiz-item choice question="Choose the correct answer" text="PAD4 has which of the following effects in the neutrophil?" options="Methylates DNA|Citrullinates arginine in histones|Phosphorylates Pi3K and Atk|Ruptured the nuclear membrane" answer="Citrullinates arginine in histones">
 </quiz>
 <accordion>
 <accordion-item title=”Explanation”>
+Citrullination of histones opens up the DNA. ROS and neutrophil elastase help cleave histone proteins. The DNA is then releases during cell lysis (suicide) or non-lytic - passed out in vesicles but neutrophil continues to live withouta nucleus for a while.
 {{ :general_pathology:acute:netosis1.png |}}
 </accordion-item>
 </accordion>